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Pharmacokinetic Modelling

Python MATLAB Nov 2024

Project guide: Dr. Maneesha Shaji, Institute Tokyo Science
I simulated basic Absorption, Distribution, Metabolism and Extraction (ADME) of a drug in a single-compartment system, in MATLAB and Python. I then performed non-linear regression on real pharmacokinetic datasets to obtain multiple best-fit curves and calculate corresponding equation constants. Currently working on adjusting the regression model to handle multiple dosages, and training a machine-learning model to automate dosage adjustments.

Single-compartment pharmacokinetic Python model with adjustable parameters

Curve-fitting using non-linear regression on dataset fk_id 129
Currently regression model is unable to calculate for multiple dosages (fk_id 147)